In partnership with

Issue #33: March 2, 2025

1 in 3 adults is walking around with a chronically dysregulated nervous system — and most of them have no idea. Not because something dramatic happened. Because modern life is just relentlessly, quietly, overwhelming.

The result is a body that never fully switches off. Stress that doesn't resolve. Sleep that doesn't restore. Inflammation that never settles. And a creeping sense that you're always slightly on edge, even when nothing is actually wrong.

A lot of that traces back to one nerve most people have never heard of: the vagus nerve.

🧠 What the Vagus Nerve Actually Is

Think of your nervous system as having two modes: a gas pedal and a brake.

The gas pedal is your sympathetic nervous system — fight or flight. It's what floods your body with cortisol and adrenaline when a car cuts you off, a deadline drops in your lap, or your inbox hits triple digits before 9am.

The brake is your parasympathetic nervous system — rest and digest. It slows your heart rate, lowers blood pressure, and signals to your body that the threat has passed and it's safe to recover.

The vagus nerve is the brake. It's the longest cranial nerve in the body, running from your brainstem all the way down through your heart, lungs, and gut — carrying signals in both directions. Brain to organs. Organs back to brain. Scientists call this the gut-brain axis, and the vagus nerve is the highway it runs on.

When vagal tone is strong:

  • You bounce back from stress quickly

  • You sleep deeply and wake restored

  • Your digestion runs smoothly

  • Your immune system stays calibrated

When vagal tone is weak, your body stays stuck in gas-pedal mode long after the actual stressor is gone.

📉 How to Know If Yours Is Weak

Vagal tone isn't something most doctors test for, but there's a simple proxy metric worth knowing: heart rate variability, or HRV.

HRV measures the variation in time between each heartbeat. Think of it less like a metronome and more like a jazz musician — a healthy heart has rhythm, but it also has flex. High HRV means your nervous system is responsive and adaptable. Low HRV means it's rigid, stuck in high-alert mode, struggling to downshift.

Most modern wearables track it automatically — Whoop, Garmin, Apple Watch, Oura Ring. If yours is consistently low relative to your age and baseline, that's worth paying attention to.

Beyond HRV, low vagal tone tends to show up as:

  • Tired at night but unable to wind down

  • Slow to recover from stressful events

  • Chronic digestive issues

  • Getting sick often

  • A low-grade anxiety that doesn't seem tied to anything specific

Sound familiar?

🔥 What Happens When the Brake Never Engages

A weak vagus nerve isn't just uncomfortable. Over time, the downstream effects are serious.

When the body stays in sympathetic overdrive, cortisol stays elevated. And sustained high cortisol is essentially a slow drip of damage — it:

  • Disrupts sleep architecture

  • Suppresses immune function

  • Accelerates cellular aging

  • Drives systemic inflammation

That last one deserves emphasis. Chronic low-grade inflammation is now understood to be a common thread running through heart disease, type 2 diabetes, depression, autoimmune conditions, and cognitive decline.

The vagus nerve directly regulates inflammatory response through what researchers call the "inflammatory reflex" — it signals the spleen to pump the brakes on pro-inflammatory cytokines. When vagal tone is low, that reflex gets sluggish. The inflammation doesn't get the message to stand down.

It's like a city that forgot to turn off its emergency alert system. The sirens keep blaring. Everyone stays tense. Nothing functions the way it should.

🧩 A Quick Word From Today’s Sponsor

Feeling off lately? It could be your hormones.

3pm crashes every day. Unexpected weight gain. Unpredictable cycles. When symptoms start piling up, your hormones and metabolic health are often part of the story.

Allara helps women understand what's really going on with comprehensive hormone and metabolic testing. Their advanced testing goes beyond the basics to measure key markers like insulin, thyroid function, reproductive hormones, and metabolic health. Whether you already have a diagnosis or are still searching for answers, Allara's care team uses your results to create a personalized treatment plan with expert medical and nutrition guidance.

They treat a wide range of women’s health conditions, including PCOS, fertility challenges, weight management, perimenopause, thyroid conditions, and more.

With Allara, you get clarity, expert support, and a personalized care plan all for as little as $0 with insurance. This isn’t about quick fixes. It’s about understanding your body and addressing the root causes.

🛠️ How To Strengthen It

This is the part that surprises most people: vagal tone is trainable. It responds to deliberate, consistent input — and most of what works is remarkably low-tech.

Breathwork — the most direct lever you have. Slow, extended exhales activate the vagus nerve more than almost anything else:

  • Inhale for 4 counts

  • Exhale for 8

  • Five minutes of this shifts HRV measurably

The exhale is the key. That's the part that triggers the parasympathetic response.

Cold exposure — finishing your shower cold, splashing cold water on your face, or full cold immersion all stimulate the vagus nerve via the dive reflex — a hardwired response that slows heart rate and activates the parasympathetic system. It sounds miserable. It works.

Humming, singing, and gargling — the muscles at the back of the throat connect directly to vagal branches. Gargling vigorously with water for 30 seconds has measurable effects on vagal tone. It sounds almost too simple. The research backs it.

Zone 2 cardio — conversational-pace exercise done consistently is one of the most reliable long-term tools for building a resilient nervous system. Not sprinting. Not crushing yourself. Just sustained, moderate movement done regularly.

Genuine social connection — the vagus nerve responds to felt safety. Real conversation, laughter, time with people you trust. This isn't soft science — it's one of the reasons chronic loneliness has such measurable effects on physical health.

💡 The Bottom Line

Most people treat stress like a mindset problem. Push through. Stay positive. Manage your time better.

But stress is also a physiology problem. And if the system designed to bring you back to baseline is underperforming, mindset alone won't override the biology.

The vagus nerve is that system. And strengthening it doesn't require expensive equipment or dramatic change. It requires consistency with tools most people already have access to:

  • Breathe intentionally

  • Move regularly

  • Sleep seriously

  • Build real human connection into your life

The brake exists. Most people just never learned how to use it.

Until next week. Stay vital.

-Jordan Slotopolsky

📚 Sources

  • Tracey KJ. The inflammatory reflex. Nature, 2002

  • Porges SW. The polyvagal theory. Biological Psychology, 2007

  • Thayer JF & Lane RD. The role of vagal function in the risk for cardiovascular disease and mortality. Biological Psychology, 2007

  • Breit S, et al. Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders. Frontiers in Psychiatry, 2018

  • Laborde S, et al. Heart rate variability and cardiac vagal tone in psychophysiological research. Frontiers in Psychology, 2017

  • Kox M, et al. Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response. PNAS, 2014

Disclaimer:

The content provided in this newsletter is for informational and educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this newsletter. The information provided does not constitute the practice of medicine or any other professional healthcare service.

Reply

Avatar

or to participate

Keep Reading